IZKF Junior Research Group 2
Welcome to the Dulin lab!
We are fascinated by protein-nucleic acid interactions, and in particular how genomes are replicated, transcribed and translated. Our aim is to understand how genome expression and maintenance are connected to diseases to discover new possible therapeutic approaches. We use high-end bespoke microscope with a highly interdisciplinary mindset, mixing biology, physics and chemistry, to observe nucleic acid molecules and/or proteins one at a time, and uncover their hidden behaviour with great precision and detail. Our lab has two main research lines: RNA viruses and cellular transcription. The Dulin lab is the Junior Research Group n°2 “Physics and Medicine” of the IZKF-Erlangen Klinikum, and we are hosted by OICE at the Interdisciplinary Center for Nanostructured Films (IZNF) of the Friedrich-Alexander University Erlangen-Nuremberg.
Despite the restrictions due to the coronavirus pandemic, 2020 has been very successful for the Dulin lab, as we have been awarded 3 individual DFG grants for this year only to study human mitochondrial transcription termination, Pol I transcription initiation, and SARS-CoV RNA synthesis! Thank you ...
We are very excited to share our latest results on how antiviral drugs stop replication of SARS-CoV-2, the virus responsible for the COVID19 pandemic. Check our preprint on bioRxiv!
Nucleotide analogues, such as Remdesivir, are our best strategy to cure SARS-CoV-2 infection. The genome of SARS-CoV-...
We are very pleased to welcome Dr. Salina Quack, who just joined the Dulin lab as a postdoc. She graduated her PhD from Ulm University under the supervision of Prof. Jens Michaelis, where she worked on nucleosome remodelers using single molecule FRET. In the Dulin lab, she will use her single molecu...
Congrats to all authors — especially to Mona — for this great work on the elongation kinetics of viral RdRps as a function of the temperature. We show here that viral RdRps from viruses that infect different organisms have a very different response to temperature increase, highlighting their special...
Congrats to Eugen and Flávia for their new publication! Special congrats to Eugen for establishing such sensitive instrument in Erlangen! We are now capable to observe single DNA base pair translocation by molecular motors.
